- Title
- Synthesis and biological evaluation of novel ocotillol-type triterpenoid derivatives as antibacterial agents
- Creator
- Zhou, Zhiwen; Ma, Cong; Zhang, Hengyuan; Bi, Yi; Chen, Xia; Tian, Hua; Xie, Xiaoni; Meng, Qingguo; Lewis, Peter John; Xu, Jinyi
- Relation
- NHMRC.APP1008014
- Relation
- European Journal of Medicinal Chemistry Vol. 68, p. 444-453
- Publisher Link
- http://dx.doi.org/10.1016/j.ejmech.2013.07.041
- Publisher
- Elsevier Masson
- Resource Type
- journal article
- Date
- 2013
- Description
- A novel class of ocotillol-type triterpenoid derivatives have been synthesized and evaluated for their in vitro antibacterial activity against several representative pathogenic bacterial strains. Compounds 20(S)-protopanaxadiol (PPD), 3, 5, 16 and 24 exhibited potent antibacterial activity against Gram-positive bacteria. Compounds 3 and 5 also displayed promising antibacterial activity against a community associated methicillin-resistant Staphylococcus aureus (CA-MRSA; strain USA300). Furthermore, compounds PPD, 3 and 16 combined with two commercially available antibiotics kanamycin and chloramphenicol showed strong synergistic inhibitory effects at their sub-MIC concentrations against S. aureus USA300 and Bacillus subtilis 168. Additionally, cytotoxic activity assay showed that the compounds tested did not affect cell viability of the human epithelial kidney (HEK-293) and human cervical (HeLa) cells at their MICs.
- Subject
- triterpenoid; ocotillol; antibacterial activity; synergistic effect; cytotoxicity
- Identifier
- http://hdl.handle.net/1959.13/1296956
- Identifier
- uon:19340
- Identifier
- ISSN:0223-5234
- Language
- eng
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